| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 21-01-25 17:45 | AS Mónaco | Aston Villa | 1:0 |
| 21-01-25 17:45 | Atalanta Bergamo | SK Sturm Graz | 5:0 |
| 21-01-25 20:00 | FC Liverpool | OSC Lille | 2:1 |
| 21-01-25 20:00 | Atlético Madrid | Bayer 04 Leverkusen | 2:1 |
| 21-01-25 20:00 | FC Brugges | Juventus Turim | 0:0 |
| 21-01-25 20:00 | Estrela Vermelha Belgrado | PSV Eindhoven | 2:3 |
| 21-01-25 20:00 | SK Slovan Bratislava | VfB Estugarda | 1:3 |
| 21-01-25 20:00 | FC Bologna | Borussia Dortmund | 2:1 |
| 21-01-25 20:00 | Benfica | FC Barcelona | 4:5 |
| 22-01-25 17:45 | Shaktiar Donetsk | Stade Brest 29 | 2:0 |
| 22-01-25 17:45 | RB Leipzig | Sporting | 2:1 |
| 22-01-25 20:00 | FC Arsenal | Dínamo Zagreb | 3:0 |
| 22-01-25 20:00 | AC Milão | FC Girona | 1:0 |
| 22-01-25 20:00 | Real Madrid | FC Red Bull Salzburgo | 5:1 |
| 22-01-25 20:00 | Paris St. Germain | Manchester City | 4:2 |
| 22-01-25 20:00 | Celtic Glasgow | Young Boys Berna | 1:0 |
| 22-01-25 20:00 | Feyenoord Rotterdão | FC Bayern Munique | 3:0 |
| 22-01-25 20:00 | Sparta Praga | Inter Milão | 0:1 |